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ZB 10 - Soft Condensed Matter (R. Holyst)
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!

Publication

Transport of nanoprobes in multicellular spheroids

Author(s): Pilz, Marta and Kwapiszewska, Karina and Kalwarczyk, Tomasz and Bubak, Grzegorz and Nowis, Dominika and Holyst, Robert
Title: Transport of nanoprobes in multicellular spheroids
Abstract: The efficient delivery of drugs to cells depends on their diffusion through the extracellular matrix (ECM) of tissues. Here we present a study of diffusion of nanoprobes of radius from 1 nm to over 100 nm in the ECM of spheroids of three cell types (HeLa, MCF-7 and fibroblasts). We quantified nanoparticle transport in spheroids’ proliferating zone. We determined the size-dependent viscosity of the ECM. We revealed that nanoobjects up to 10 nm in radius exhibited unobstructed diffusion in the ECM, regardless of the spheroid type. Presented length-scale dependent viscosity profiles for spheroids pave the way for advanced modelling of drug administration through tissue.
Journal: Nanoscale
Publisher: The Royal Society of Chemistry
Year: 2020
URL: http://dx.doi.org/10.1039/D0NR01986K
DOI: 10.1039/D0NR01986K

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