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ZB 10 - Soft Condensed Matter (R. Holyst)

We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!




We invite you to a new group webpage!




A great success from SERSitive! We are very pleased to inform you that SERSitive and its project "Platform for surface-enhanced Raman spectroscopy for diagnostic and biomedical purposes" was awarded in the "Polish Product of the Future" competition organized by the Polish Agency for Enterprise Development (PARP) and the National Center for Research and Development (NCBiR).


The member of our #hołyst_team - Dr. Paweł Żuk (post-doc from PD2PI) received a scholarship from the Polish Ministry of Education and Science. Congrats Paweł!

The results were announced here.



Krzysztof Bielec defended his PhD thesis! Congrats! 

Formation of chemical complexes at subnanomolar concentration scale

Advisor: prof. dr hab. Robert Hołyst
Reviewers: prof. dr hab. Renata Gadzała-Kopciuch (Uniwersytet Mikołaja Kopernika w Toruniu), prof. dr hab. Wojciech Dzwolak (Uniwersytet Warszawski), dr hab. Jacek Gapiński, prof. UAM (Uniwersytet im. Adama Mickiewicza w Poznaniu)


A new paper about the mechanisms of binding YOYO to dsDNA was published.

Two Intercalation Mechanisms of Oxazole Yellow Dimer (YOYO-1) into DNA

Karolina Kucharska, Marta Pilz,Krzysztof Bielec,Tomasz Kalwarczyk, Patrycja Kuźma and Robert Hołyst

Molecules 2021, 26(12), 3748; https://doi.org/10.3390/molecules26123748


Professor Robert Hołyst was awarded a PRELUDIUM BIS grant. A new PhD student will be recruited this summer! 

High-throughput microfluidic system for rapid determination of the equilibrium constant of complex formation between biomolecules: application to the interaction of RNA with DNA



We would like to inform you, that article titled 'Transport of nanoprobes in multicellular spheroids', Marta Pilz et. al has been specially selected by Professor Yves Dufrêne to feature in an Editor’s Choice web collection focussing on recent breakthroughs in nanobiotechnology!!!!

Congratulations Marta and other authors from our Team!

More info here!



SERSitive got a new patent!

Method for depositing metal nanoparticles on a surface in the electrochemical process, surface obtained by this method and its application

Monika Księżopolska-Gocalska, Paweł Albrycht, Joanna Niedziółka-Jonsson, Ewa Roźniecka, Marta Podrażka, Robert Hołyst



The next paper from our Team is published! 

Macroscopic Viscosity of Polymer Solutions from the Nanoscale Analysis

Airit Agasty, Agnieszka Wisniewska, Tomasz Kalwarczyk, Kaloian Koynov, and Robert Holyst 
ACS Appl. Polym. Mater. 2021

You can read more here!



We are happy to announce that another paper was published. This time in collaboration with Paczesny group, Niedziółka-Jönsson group (both from IPC), Professor Gapiński (UAM, Poznan), and Professor Łoś (UG, Gdańsk).

"When in the lab, carefully choose consumables!"

Adsorption of bacteriophages on polypropylene labware affects the reproducibility of phage research

Richter et al.
Scientific Reports volume 11, Article number: 7387 (2021) https://doi.org/10.1038/s41598-021-86571-x



We highly recommend you to read an article about one of our last papers - Bubak et al. "Quantifying Nanoscale Viscosity and Structures of Living Cells Nucleus from Mobility Measurements”

Congrats Grzegorz! Read more here!




Dr Michalina Iwan and Dr Tomasz Andryszewski joined our team. You are most welcome!


It is with great difficulty we share with you that our friend and collaborator, Professor Marcin Fiałkowski, passed away.

We share a fragment of personal reminiscences about Prof. Marcin Fiałkowski by
Dr. Olgierd Cybulski (currently at UNIST, South Korea):

Thanks to Marcin that I started to think about a doctorate at the IPC PAS - if not for a chance meeting in the Cracow institute's corridor, I would probably still be stuck there as an electronics technician driving in screws to this day.

Marcin, wherever you are now, whoever you are working for, I will be happy to join you there someday with a beaker of freshly brewed tea.


A new paper from our Group!

Our post-doc from the NAWA program - Jeffrey Everts - published a paper in PHYSICAL REVIEW X.

Ionically Charged Topological Defects in Nematic Fluids
Phys. Rev. X 11, 011054 – Published 16 March 2021


We are proud of you Jeffrey! Congratulations!


Jeffrey has his first paper published with the IPC PAS affiliation. Congrats!

Anisotropic electrostatic screening of charged colloids in nematic solvents

Jeffrey C. Everts, Bohdan Senyuk, Haridas Mundoor, Miha Ravnik, Ivan I. Smalyukh

Science Advances  27 Jan 2021: Vol. 7, no. 5, eabd0662 DOI: 10.1126/sciadv.abd0662



We got a patent granted!

Method for deposition of analyte from solution onto the substrate for surface enhanced spectroscopy in the electric field

Richter, Ł.; Paczesny, J,; Księżopolska-Gocalska, M.; Hołyst, R.P.412548


First paper with a date from 2021! Congrats!

Quantifying Nanoscale Viscosity and Structures of Living Cells Nucleus from Mobility Measurements

Grzegorz Bubak, Karina Kwapiszewska, Tomasz Kalwarczyk, Krzysztof Bielec, Tomasz Andryszewski, Michalina Iwan, Szymon Bubak, and Robert Hołyst*

J. Phys. Chem. Lett. 2021, 12, 1, 294–301




The Hołyst Group is entering into plant biology

Members of our group visited the group of Dr. Aleksandra Obrępalska-Stęplowska in the Department of Molecular Biology and Biotechnology in the Institute of Plant Protection, National Research Institute.

Prof. Robert Hołyst, Dr. Karina Kwapiszewska, and Aneta Karpińska learned about plants, their pathogens, and research methods in plant biology. They also visited The Research Centre of Quarantine, Invasive, and Genetically Modified Organisms.

We are now performing pilot experiments and preparing for research collaboration. We are excited about this new, extraordinary challenge!




Dr. Tomasz Zajkowski is an employee of the Center of New Technologies at the University of Warsaw, currently conducting his individual research project at NASA Ames Research Center. He is interested in how simple chemical components organize themselves into higher-order structures, giving rise to biological processes. By using the genetic information of modern organisms, he tries to recreate the processes that took place in the early stages of evolution. 

More info: http://astrobio.pl/zajkowski/

Link to the video of that lecture: https://www.youtube.com/watch?v=NKVIe5SQX2Y


Professor Robert Hołyst will be a guest of Cezary Łasiczka on TOK FM radio at 10 AM on Friday, 04th of December 2020. The audition will be on Dream Chemistry Award, which is organized jointly by the Institute of Physical Chemistry of the Polish Academy of Sciences and the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences. The audition will be available online https://www.tokfm.pl/Tokfm/0,0.html


We highly recommend an interview with a member of our Team - Dr. Karol Makuch. Karol describes his work on understanding the problem of the work of antibiotics.

Karol obtained a scholarship within Bekker program founded by the Polish National Agency for Academic Exchange NAWA. This allowed him to spend one year at Caltech, The California Institute of Technology in Pasadena, USA, where he started his work on non-equilibrium physics in the context of experiments on bacterial antibiotic resistance.

You can read it here!



Dream Chemistry Award winner is.... Claudia Bonfio and her dream on “Unlocking Primitive Chemical Messages” Congratulation!








Dream Chemistry Award is a unique contest in which a prize is awarded to a young scientist with a chemistry background for an idea of a scientific project in the field of chemistry or chemistry-related disciplines that she/he dreams to solve. The applications are assessed based on the originality of the proposal; the CV of the Candidate is considered as well.

2020 edition agenda

Day 1 November 30th, 18.00-22.00 https://www.youtube.com/watch?v=DW5PZ_JlANQ

Talks by five nominees Yunyan Qiu, Northwestern University, USA, Claudia Bonfio, University of Cambridge, UK, Pawel Dydio, Universite de Strasbourg, ISIS, France, Ivana Drienovska, Vrije Universiteit Amsterdam, The Netherlands, Christopher Hendon, University of Oregon, USA.

Day 2 December 1st, 18.00-21.00  https://www.youtube.com/watch?v=JPyRJDlVF2g

Award Ceremony and SPECIAL EVENT (Russell Johnson, Editor at Nature Chemistry
“Perspectives on the chemistry publishing landscape”)





Professor Holyst gave lecture inaugurating the beginning of the academic year in the Jerzy Haber Institute of Catalysis and Surface Chemistry of Polish Academy of Sciences on 22nd of October 2020. The talk was on movement inside the crowded environment of the cell.



We welcome new students who have joined the group! You can read more about them in the section "People".

top row, from the left: Adam Kowalski, Zuzanna Pieczara, Maciej Czajkowski, Joanna Buczkowska
bottom row, from the left: Jarosław Michalski, Krzysztof Kolankowski, Klaudia Lutyk



Review article on "Application of Bacteriophages in Nanotechnology", coauthored by Jan Paczesny and Krzysztof Bielec, was published in Nanomaterials (IF=4).

Nanomaterials 2020, 10(10), 1944; https://doi.org/10.3390/nano10101944


SERSitive got two patent granted!

P.408785 The method of electrochemical deposition of metal nanoparticles on surface, the surface obtained by this method and the use thereof

Monika Księżopolska-Gocalska, Weronika Michałowicz, Marta Siek, Joanna Niedziółka-Jonsson, Marcin Opałło, Robert Hołyst

P.412548 Method for deposition of analyte from solution onto the substrate for surface enhanced spectroscopy in the electric field

Łukasz Richter, Jan Paczesny, Monika Księżopolska-Gocalska, Robert Hołyst


Again two papers within a week! DCs Anna Maciolek published a paper in Soft Matter as a result of collaboration between groups from Universidad Nacional Autonoma de México, Max-Planck-Institut für Intelligente Systeme, Universität Stuttgart and Kyoto University.

Transient coarsening and the motility of optically heated Janus colloids in a binary liquid mixture

Juan Ruben Gomez-Solano, Sutapa Roy, Takeaki Araki, S. Dietrich and Anna Maciołek  

Soft Matter, 2020, DOI: 10.1039/D0SM00964D 



New paper was accepted for publication. Congrats!

Transport of nanoprobes in multicellular spheroids

Marta Pilz, Karina Kwapiszewska, Tomasz Kalwarczyk, Grzegorz Bubak, Dominika Nowis and Robert Holyst  

Nanoscale, 2020, Accepted Manuscript https://doi.org/10.1039/D0NR01986K



Karol Makuch, PhD, joined the group some time ago! This is what Karol says about himself:

I trained in theoretical physics at the University of Warsaw, where I worked on soft and quantum condensed matter. After 2015 I joined microfluidic group at the Institute of Physical Chemistry of the Polish Academy of Sciences, where I have been involved in microfluidic and biophysical experiments. I have also worked on transport of molecules in complex fluids and inside living cells. From March 2019 to March 2020 I visited the active matter group at the California Institute of Technology. More information: www.karolmakuch.com




Since its online publication on Jul 06, 2012, there have been a total of 45902 chapter downloads for "Thermodynamics for Chemists, Physicist and Engineers" by Robert Hołyst and Andrzej Poniewierski. The book was among the top 25% most downloaded eBooks in its respective eBook Collection in 2019.





Second paper during this week (and it is Tuesday!). The work was done in collaboration with Nencki Institute of Experimental Biology.

Nanoscale Viscosity of Cytoplasm Is Conserved in Human Cell Lines

Karina Kwapiszewska,Krzysztof Szczepański, Tomasz Kalwarczyk, Bernadeta Michalska, Paulina Patalas-Krawczyk, Paulina Patalas-Krawczyk, Jedrzej Szymanski, Tomasz Andryszewski, Michalina Iwan, Jerzy Duszyński, and Robert Hołyst






New paper authored by Jan Paczesny, Łukasz Richter and Robert Hołyst was published in Viruses.

Recent Progress in the Detection of Bacteria Using Bacteriophages: A Review







Join IPC PAS and do a great science (and it is fun too!). Among projects awaiting for PhD candidates within Warsaw4PhD doctoral school, there are three that we recommend the most!


3.9. Study of nanoviscosity changes during cell death (Prof. dr hab. Robert Hołyst/Co-supervisor: Dr inż. Karina Kwapiszewska)

3.11. Assembly of particle chains based on dielectrophoretic, magnetic and capillary effects (Prof. dr hab. Robert Hołyst/Co-supervisor: Dr Konrad Giżyński)

3.20. Bacteriophage-based biosensors for bacteria detection (Prof. dr hab. Robert Hołyst/Co-supervisor: dr Jan Paczesny)






We are recruiting!

We search for a Ph.D. Candidate to the project of Dr. Karina Kwapiszewska ("Changes of intracellular transport during cell death").

More information about position and recruitment are available at:







Robert Holyst and Tomek Kalwarczyk were listed as coauthors of the paper

Photoluminescent, Ferromagnetic, and Hydrophobic Sponges for Oil–Water Separation

published in ACS Omega https://pubs.acs.org/doi/10.1021/acsomega.0c00899


We have missed the information that Karol Makuch and Krzysztof Sozański were listed as coauthors of paper entitled

Droplet-based digital antibiotic susceptibility screen reveals single-cell clonal heteroresistance in an isogenic bacterial population

published in February in Scientific Reports volume 10, Article number: 3282 (2020)



2020 is not that bad of a year overall. Another paper was accepted for publication. Ying Zhou, Krzysztof Bielec, and Robert Holyst coauthored the piece accepted in Analyst.

Single molecule brightness analysis for determination of anticancer drugs interactions with DNA

Ying Zhou, Krzysztof Bielec, Pakorn Pasitsuparoad and  Robert Hołyst

Analyst, 2020, Advance Article



Jeffrey Everts joined the group of prof. dr. Robert Hołyst as an Ulam individual fellow funded by the Polish National Agency of Academic Exchange (NAWA). Prior to this postdoc position he obtained his BSc degree in chemical engineering and applied physics at Eindhoven University of Technology in 2010 (both graduated with highest distinction, cum laude), and a MSc degree in theoretical physics at Utrecht University in 2012 (graduated with highest distinction, cum laude). During his studies he was already active in research, working on topological insulators and supramolecular self-assembly. Subsequently, he performed his PhD studies with prof. dr. René van Roij on charged colloidal suspensions at Utrecht University which he finished in 2016. Later, from 2017-2020 he was a postdoc in topological soft matter with prof. dr. Miha Ravnik at the University of Ljubljana as a Marie Skłodowska-Curie individual fellow. His current research interests are transport properties of (interacting) complex fluids in biological settings, ion-doped liquid crystals for liquid-like microelectronics and ion electrostatics of charged colloidal suspensions.

More info can be found on his personal website: https://sites.google.com/view/jeffreyeverts/home



Three papers per week - only in #hołyst_team!

Paweł Albrycht is co-author of the paper

Fabrication of nanocages on nickel using femtosecond laser ablation and trace level detection of malachite green and Nile blue dyes using surface enhanced Raman spectroscopic technique

which is accepted for publication in Optics & Laser Technology.





We got another paper accepted for publication, this time in Physical Review Letters. The piece was done in collaboration with groups of Professor Piotr Garstecki (IPC PAS), Professor Howard A. Stone (Princeton University) and Professor Carlos Drummond (CNRS, Unversite de Bordeaux).

Ions in an AC electric field: Strong long-range repulsion between oppositely charged surfaces

Łukasz Richter, Paweł J. Żuk, Piotr Szymczak, Jan Paczesny, Krzysztof M. Bąk, Tomasz Szymborski, Piotr Garstecki, Howard A. Stone, Robert Hołyst, and Carlos Drummond

Phys. Rev. Lett. 2020 just accepted




Another paper was published in cooperation with Max Planck Institute for Polymer Research. Congratulation!

Scaling equation for viscosity of polydimethylsiloxane in ethyl acetate: From dilute to concentrated solutions
Airit Agasty, Agnieszka Wisniewska, Tomasz Kalwarczyk, Kaloian Koynov, Robert Holyst

Polymer, available online 6 July 2020, 122779




We are on fire!

TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats

Marta Gawrys-Kopczynska, Marek Konop, Klaudia Maksymiuk, Katarzyna Kraszewska, Ladislav Derzsi, Krzysztof Sozanski, Robert Holyst, Marta Pilz, Emilia Samborowska, Leszek Dobrowolski, Kinga Jaworska, Izabella Mogilnicka, Marcin Ufnal

eLife 2020;9:e57028




Another paper was published!

Joint effect of surfactants and cephalexin on the formation of Escherichia coli filament
Hou, S., Jia, Z., Kryszczuk, K., Chen, D., Wang, L., Holyst, R., Feng, X.

Ecotoxicology and Environmental Safety Volume 199, August 2020, 110750




Good news! The work on cell extract gels was accepted for publication. Congrats!

Cell extract gels as an example of active matter

Agnieszka Wisniewska, Tomasz Kalwarczyk, Jedrzej Szymanski, Katarzyna Kryszczuk, Kinga Matula & Robert Holyst

Rheologica Acta (2020)



Professor Robert Hołyst was a guest of Łukasz Badowski in RDC Radio talking on the viscosity of cells. You can listen to him here (in Polish).



Robert Hołyst and Tomasz Kalwarczyk were listed as coauthors of the work:

Self-Stabilized Giant Aggregates in Water from Room-Temperature Ionic Liquids with an Asymmetric Polar–Apolar–Polar Architecture
by Geping Zhang, Hongxia Zhu, Jingfei Chen, Mengjun Chen, Tomasz Kalwarczyk, Robert Hołyst, Hongguang Li, and Jingcheng Hao

J. Phys. Chem. B 2020, 124, 22,



New paper was published!

Storage of Energy in Constrained Non-Equilibrium Systems
by Yirui Zhang, Konrad Giżyński, Anna Maciołek and Robert Hołyst

Entropy 2020, 22, 557




COVID19 does not stop us from publishing quality content! DSc Anna Maciołek along with collaborators published work:

Critical Casimir interaction between colloidal Janus-type particles in two spatial dimensions
by A Squarcini, A Maciołek, E Eisenriegler and S Dietrich

Journal of Statistical Mechanics: Theory and Experiment, 2020, 043208




We missed the information on paper co-authored by Pawel Albrycht in 2019

Features and advantages of flexible silicon nanowires for SERS applications
by Hrvoje Gebavi, Vlatko Gašparić, Dubravko Risović, Nikola Baran, Paweł Henryk Albrycht  and Mile Ivanda

Beilstein J. Nanotechnol. 2019, 10, 725–734. doi:10.3762/bjnano.10.72



The Spokesmen of Science (see their web page) received prestigious Science Populariser 2019 award. Jan Paczesny and Łukasz Richter are members of the association! You can read more here (in Polish).



February is breathtaking! Another paper was accepted for publication.

Fast and efficient deposition of broad range of analytes on substrates for surface enhanced Raman spectroscopy
Łukasz Richter, Paweł Albrycht, Monika Księżopolska-Gocalska, Ewa Poboży, Robert
Bachliński, Volodymyr Sashuk, Jan Paczesny, Robert Hołyst

Biosensors and Bioelectronics, 2020, just accepted. Read more here.



We are happy to announce that there is another paper published comming from our group.

Analysis of Brightness of a Single Fluorophore for Quantitative Characterization of Biochemical Reactions
Krzysztof Bielec, Grzegorz Bubak, Tomasz Kalwarczyk, Robert Holyst

published in J. Phys. Chem. B. You can read more here. Congrats!

Krzysztof gave talk on the published results at the Institute for Life Sciences in Southampton in the group of Professor Hywel Morgan (18.02.2020).


Another paper comming from our group! Paweł Albrycht and Karolina Paszkowska co-authored (along with group from Szeged, Hungary) publication entitled:

Nanoparticle enhanced LIBS spectroscopy of liquid samples by using modified surface-enhanced Raman scattering substrates
Dávid J. Palásti,* Pawel Albrycht,* Patrick Janovszky, Karolina Paszkowska, Zsolt Geretovszky, Gábor Galbács (*equal contribution)

published in Spectrochimica Acta Part B: Atomic Spectroscopy. You can read more here. Congrats!


Łukasz Richter was listed as co-author of a paper along with researchs from Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Centre de recherche en photonique, Université du Québec en Outaouais, Baltic Institute of Technology and Warsaw University of Technology published in Sensors 2020, 20(3), 813.

Immunosensor Based on Long-Period Fiber Gratings for Detection of Viruses Causing Gastroenteritis
by M. Janczuk-Richter, B. Gromadzka, Ł. Richter, M. Panasiuk, K. Zimmer, P. Mikulic, W. J. Bock, S. Maćkowski, M. Śmietana and J. Niedziółka Jönsson.

You can read more here. Congrats!


The new year 2020 and a new paper from our group!

Yirui Zhang - PhD Student from our Team and DSc Anna Maciołek & Professor Robert Hołyst published an article 

Energy storage in steady states under cyclic local energy input

in Phys. Rev. E. Congratulations!

You can read more here.


On 3rd of February Kinga Matuła defended her PhD thesis entitled: "Influence of physical and chemical factors on evolution of cells”. Her thesis was honorary mentioned! Congrats!

Supervisor: Professor Robert Hołyst
Auxilary supervisor: Jan Paczesny, PhD



On January 31st and February 1st, 2020, Professor Hołyst attended a conference titled:

Future of the sciences in the light of authorship laws, researcher’s ethical codes and government evaluations of the quality of research

organized by the Polish-U.S. Fulbright Commission in collaboration with the Faculty of Law and Administration, University of Silesia.




Professor Holyst gave a talk on a new method of science evaluation (according to Act 2.0) during Congress of the Deans of Chemistry Faculties, which took place in Poznan from 23rd to 24th of January.


We celebrated Professor Robert Holyst birthday! :)


Kinga Matula passed her doctoral and philosophy exams on 21st of January! She will defend her thesis entitled "Influence of physical and chemical factors on evolution of cells" on 3rd of February (9.00) in Main Hall of IPC PAS. You are all welcome to attend!



Good news at the end of the year! Another paper co-authored by Anna Maciolek, DSc, was published! Congrats!

Criticality senses topology

O. A. Vasilyev1,2, A. Maciolek1,2,3 and S. Dietrich1,2

EPL, 128 (2019) 20002
doi: 10.1209/0295-5075/128/20002

1. Max-Planck-Institut für Intelligente Systeme - Heisenbergstraße 3, D-70569 Stuttgart, Germany
2. Institut für Theoretische Physik, Universität Stuttgart - Pfaffenwaldring 57, D-70569 Stuttgart, Germany
3. Institute of Physical Chemistry, Polish Academy of Sciences - Kasprzaka 44/52, PL-01-224 Warsaw, Poland


Robert Holyst gave a talk at the Polish Chemical Society (8 November 2019, Poznan) entitled:

Diffusion and viscosity - one hundred years after Albert Einstein


In biology, the liquids, which fill the interior of cells, are complex by presenting structure at multiple relevant length scales. Diffusion of biomolecules in such systems does not follow the  Stokes-Einstein relation between the diffusion coefficient, viscosity  and the size of the diffusing objects, because  this relation is valid for dilute solutions only. The discrepancy between theory and experiment reaches orders of magnitude in the value of the diffusion coefficient measured in complex liquids.
In my talk I will fill this apparent gap in our understanding and predicting diffusion of solute particles in complex liquids such as: interior of living cells, micellar solutions, colloidal suspensions, polymer solutions etc. I will present conclusions drawn from 15 years of experimental work of my group and the final generalization of the Stokes-Einstein relation for complex liquids.
The final formula relating diffusion coefficient, viscosity of a complex liquid and the size of diffusing object is as elegant and in fact simple as the original formula of Albert Einstein, yet of much wider applicability.



Karolina Księżarczyk presented her results on "Chemical modification of phage stabilization" during The 2nd Asian Symposium on Cutting-edge Biotechnology and Chemistry (2nd ASCBC), which took place in Kitakyushu, Japan, from 5th to 6th of December 2019.

Karolina is currently working in Professor Takenaka group at Department of Applied Chemistry, Kyushu Institute of Technology, Japan within 3 months internship.


We are pleased to inform, that another grant was awarded to our team!

Dr Karina Kwapiszewska got over 1.5 million PLN within OPUS17 programme (National Science Centre) for the project

Changes of intracellular transport during cell death

The goal of the project is to describe early physical symptoms of fatal changes in cells.

There will be open positions for PhD and MSc students within this project. Follow our website in near future for more information.


We welcome new member of group - Alicja Kijewska.

PhD student under supervision of Karina Kwapiszewska and Robert Hołyst. Alicja graduated from the Warsaw University of Technology (Material Science and Engineering). Since the third year of studies, she had been doing internships in various companies and institutes such as Paradyż sp.zo.o., National Institute for Materials Science and Center of Polymer and Carbon Materials PAS. Her research will be focused on the changes of intracellular transport during cell death. 


There is more great news this month! Yet another paper has been published coming from our group. Krzysztof Szczepański, Karina Kwapiszewska and Robert Hołyst published a piece on nanoviscosity of cytoplasm throughout the cell cycle (it is stable!)

Stability of cytoplasmic nanoviscosity during cell cycle of HeLa cells synchronized with Aphidicolin
Krzysztof Szczepański, Karina Kwapiszewska and Robert Hołyst

Scientific Reports volume 9, Article number: 16486 (2019)

Read more here!


Tomasz Kalwarczyk & prof. Hołyst in collaboration with our friends from Garstecki Lab - Karol Makuch and prof. Garstecki & prof. Brady from Caltech USA published one of the most interesting papers about diffusion and flow in complex liquids.

Diffusion and flow in complex liquids
Karol Makuch, Robert Hołyst, Tomasz Kalwarczyk, Piotr Garstecki and  John F. Brady

Soft Matter DOI 10.1039/C9SM01119F

You can read it here!


We are pleased to inform, that method developed by us, which allows for the safe storage of viruses over a prolonged time was awarded the bronze medal at International Warsaw Invention Show 2019 (14-16.10.2019).

The title of the invention was: The method of surface modification of polymer vessels for storing virus suspensions ensuring the stability of the titers of these suspensions, the use of such vessels for storing virus suspensions, and the method of storage of virus suspensions ensuring the stability of the titers of these suspensions.

Authors: Łukasz Richter, Karolina Paszkowska, Karolina Księżarczyk, Jan Paczesny, Robert Hołyst.



Karolina Księżarczyk started her 2 months internship in the Professor Takenaka group at Kyushu Institute of Technology, Fukuoka, Japan.



Karolina Kucharksa and Maciej Skrzeszewski are new PhD student in our group. They will work on interactions between drugs and DNA under the supervision of Tomasz Kalwarczyka and Robert Hołyst.



DSc Anna Maciołek coauthored yet another paper!

Drag Force for Asymmetrically Grafted Colloids in Polymer Solutions
Matthias Werner, Paolo Margaretti, and Anna Maciołek

Front. Phys., 04 September 2019 | https://doi.org/10.3389/fphy.2019.00122

which is a part of the Research Topic: Anomalous Transport: Applications, Mathematical Perspectives, and Big Data

We consider the situation in which a colloidal particle modifies locally the solvent leading to a spatially dependent viscosity. This situation is typical for colloidal particles in a crowded environment, for example, DNA-grafted particles in a polymer solution, or a hot particle that implies a temperature gradient to a viscous liquid. By means of suitable approximations, we calculate the dependence of the friction force on the profile of the local viscosity. Our results show that in the case of axially symmetric viscosity profile the friction force is sensitive to the anisotropy of the viscous profile whereas it is not sensitive to for-ahead asymmetries. Our results are crucial for active microrheology measurements where tracer particles are pulled through complex fluids.



Jan Paczesny, PhD, gave an invited talk during 62nd meeting of the Polish Chemical Society entitled:

Examples of physicochemical approach to studies on bacteriophages



Another proof that in science during "Holiday Break" we still scientists! A new paper is published by our group!

Marta Pilz & Professor Hołyst published the paper in collaboration with Medical Research Groups and Laboratory of Molecular Bases of Aging

TMA, A Forgotten Uremic Toxin, but Not TMAO, Is Involved in Cardiovascular Pathology

in Toxins. You can read more here: https://www.mdpi.com/2072-6651/11/9/490/htm



DSc Anna Maciołek coauthored yet another paper this year! Congrats!

Correlations and forces in sheared fluids with or without quenching
Christian M Rohwer, Anna Maciołek, S Dietrich, and Matthias Krüger

Published 17 July 2019 • © 2019 The Author(s). Published by IOP Publishing Ltd on behalf of the Institute of Physics and Deutsche Physikalische Gesellschaft

New Journal of Physics, Volume 21, July 2019



We are recruiting for a new PhD program in the IPC PAS within Warsaw4PhD school!


We invite you to apply for:

3.6 Quantification of anthracyclines drugs interactions with intranuclear DNA in living cells on the example of daunorubicin

3.7 Quantification of anthracyclines drugs interactions with intranuclear DNA in living cells on the example of idarubicin

3.9 Bacteriophage based sensors for detection of pathogenic bacteria

3.10 Unusual building blocks for equilibrium and dynamic self-assembly in 2D systems



We are pleased to welcome a new PhD Student to our group!

Aneta Karpińska will join LIDER grant (leader: Karina Kwapiszewska) and will conduct research on the internalization of chemical and biological molecules into living cells.

Aneta graduated biotechnology (master's degree, specialization Medicines, and Cosmetics) from the Faculty of Chemistry at Warsaw University of Technology. As a part of her engineering thesis, she conducted research on the inactivation of bacteriophages by the electric field (with Łukasz Richter and Jan Paczesny). Afterward, she started cooperation with the National Medicines Institute, where she carried out master's research.

Since the second year of studies, Aneta had been doing internships in various companies and institutes such as the Institute of Organic Chemistry PAS, the Institute of Physical Chemistry PAS, and the Dr Irena Eris Cosmetic Laboratory. Her main fields of interest are microbiology and researches related to the introduction of new drugs to the market.

In her free time, Aneta travels a lot and hikes in the mountains.


Łukasz Richter and Paweł Albrycht attended 10th International Conference on Advanced Vibrational Spectroscopy, which was held in Auckland (New Zealand) from 7-12 July 2019. Łukasz had an oral presentation in “Surface spectroscopy, plasmonics, SERS & SEIRA” Session. Paweł represented SERSitive initiative, which was the proud sponsor of ICAVS10 conference.

ICAVS is one of the biggest conferences focused on vibrational spectroscopy, organized every two years. This year it brought up to 300 chemists, physicists, and biologists working in the field of vibrational spectroscopy.


DSc Anna Maciołek has presented the oral contribution entitled

Current-mediated synchronization of a pair of beating non-identical flagella

at the 27th IUPAP International Conference on Statistical Physics, StatPhys27, that took place in Buenos Aires, Argentina, on July 8-12, 2019.


Patrycja Tworzydło, Eng. and Katarzyna Bury, Eng. joined our team for summer internships. They came to Warsaw from Cracow, where they study at Cracow University of Technology.


Summer is the best time for internships! Mateusz Wójcik spent the last two weeks in our research group. Mateusz is a high school student and finalist of the Polish National Chemistry Olympiad.

In the first part of the internship, he worked with Dr. Grzegorz Bubak and MSc Patrycja Kuźma. Mateusz studied the diffusion of fluorescent probes in cells and in vitro conditions using FCS technique. The second week was the time to cooperate with MSc Eng. Karolina Paszkowska and MSc Karolina Księżarczyk. The research concerned the study of populations of viruses and bacteria and their survival at high temperatures.

Good Job Mateusz! We wish you all the best!


DSc Anna Maciołek is on fire! She co-authored another paper:

Illumination-induced motion of a Janus nanoparticle in binary solvents
Takeaki Araki and Anna Maciołek, Soft Matter, 2019,15, 5243-5254, https://doi.org/10.1039/C9SM00509A

Using a fluid particle dynamics method we numerically investigate the motion of a spherical Janus particle suspended in a binary liquid mixture, which emerges under heating of one-half of a colloid surface. The method treats simultaneously the flow of the solvent and the motion of the particle, hence, the velocity of the particle can be computed directly. Our approach accounts for a phenomenon of critical adsorption, therefore, a particle that is adsorptionwise nonneutral is always completely covered by an adsorption layer (droplet). In order to establish the mechanism of self-propulsion, we study systematically various combinations of adsorption preference on both hemispheres of the Janus colloid as function of the heating power for symmetric and nonsymmetric binary solvents and for various particle sizes in three spatial dimensions. Only for a particle for which the heated hemisphere is neutral whereas the other hemisphere prefers one of the two components of the mixture does the reversal of the direction of motion occur. The particle self-propels much faster in nonsymmetric binary solvents. Self-propulsion originates from a gradient of mechanical stress, in a way similar to the Marangoni effect. This stress is not localized at the edge but distributed within the whole droplet. We compare our findings with the experimental observations and other theoretical results.


Another paper coming from our group!

​Phenotypic plasticity of Escherichia coli upon exposure to physical stress induced by ZnO nanorods

​was just accepted for publication in Scientific Reports (IF=4.1).

​This piece is a result of broad collaboration between:

​Kinga Matuła, Łukasz Richter, Marta Janczuk-Richter, Wojciech Nogala, Mikołaj Grzeszkowiak, Barbara Peplińska, Stefan Jurga, Elżbieta Wyroba, Szymon Suski, Henryk Bilski, Adrian Silesian, Hans A. R. Bluyssen, Natalia Derebecka, Joanna Wesoły, Joanna M. Łoś, Marcin Łoś, Przemyslaw Decewicz, Lukasz Dziewit, Jan Paczesny,* Robert Hołyst*



Łukasz Richter, PhD, Eng., is presenting his work on electric field-assisted SERS during Polish Photoscience Seminar 2019. Łukasz received an award for his talk granted by Conference Scientific Committee.



Łukasz Richter defended his PhD dissertation entitled:

Application of the electric and magnetic fields in sensors and biosensors​. ​

The work was honorary mentioned! Congrats for dr inż Łukasz Richter!



​The 5th International Soft Matter Conference (ISMC2019) was held in Edinburgh, United Kingdom from 3-7 June 2019. Karolina Księżarczyk and Karolina Paszkowska had poster presentations in Living Matter Session. The conference brought up to 300 experimentalists and theorists working in the soft matter field.



Karolina Księżarczyk, Karolina Paszkowska, Jacek Kędzierski and Łukasz Richter proudly represented our group during 8th Intercollegiate Biotechnology Symposium "Symbioza". Karolina Księżarczyk and Jacek Kędzierski presented posters, whereas Karolina Paszkowska and Łukasz Richter had oral presentations. We are also happy to announce that Łukasz Richter was awarded with Audience Award for the best oral presentation.



Systems kept out of equilibrium in stationary states by an external source of energy store an energy dU = U − U0. U0 is the internal energy at equilibrium state, obtained after the shutdown of energy input. We determine dU for two model systems: ideal gas and a Lennard-Jones fluid. dU depends not only on the total energy flux, JU, but also on the mode of energy transfer into the system. We use three different modes of energy transfer where the energy flux per unit volume is (i) constant, (ii) proportional to the local temperature, and (iii) proportional to the local density. We show that dU/JU = τ is minimized in the stationary states formed in these systems, irrespective of the mode of energy transfer. τ is the characteristic timescale of energy outflow from the system immediately after the shutdown of energy flux. We prove that τ is minimized in stable states of the Rayleigh Benard cell.

Flux and storage of energy in nonequilibrium stationary states
Robert Holyst, Anna Maciołek, Yirui Zhang, Marek Litniewski, Piotr Knychała, Maciej Kasprzak, Michał Banaszak

Physical Review E, 99, 042118 (2019), DOI:10.1103/PhysRevE.99.042118




Another paper from our group is available online! Krzysztof Bielec, Krzysztof Sozański (leading authors), Zosia Dziekan, and Robert Hołyst along with Marco Seynen and Pieter Rein ten Wolde from FOM Institute at AMOLF (the Netherlands) published a piece on kinetics and equilibrium constants of oligonucleotides at low concentrations.

Kinetics and equilibrium constants of oligonucleotides at low concentrations. Hybridization and melting study
Krzysztof Bielec, Krzysztof Sozanski, Marco Seynen, Zofia Dziekan, Pieter Rein ten Wolde, Robert Holyst

Phys. Chem. Chem. Phys., 2019, Accepted Manuscript, 10.1039/C9CP01295H




Congratulations to Karina Kwapiszewska (leading author) and all coauthors of a new paper published online on 11th of April in Scientific Reports. The work was done in collaboration with the group of Professor Jerzy Duszyński from the Nencki Institute of Experimental Biology.

Determination of oligomerization state of Drp1 protein in living cells at nanomolar concentrations
Karina Kwapiszewska, Tomasz Kalwarczyk, Bernadeta Michalska, Krzysztof Szczepański, Jędrzej Szymański, Paulina Patalas-Krawczyk, Tomasz Andryszewski, Michalina Iwan, Jerzy Duszyński & Robert Hołyst

Scientific Reports volume 9, Article number: 5906 (2019)



Yirui Zhang is visiting scholar at Max Planck Institute for Intelligent Systems in Stuttgart, Germany. She is there from 20th of April to 20th of June 2019.


Yet another paper from our group!

Current-mediated synchronization of a pair of beating non-identical flagella
V S Dotsenko, A Maciolek, G Oshanin, O Vasilyev, and S Dietrich

Published 28 March 2019  Published by IOP Publishing Ltd on behalf of the Institute of Physics and Deutsche Physikalische Gesellschaft
New Journal of Physics, Volume 21, March 2019





In a collaboration with Bartosz Grzybowski group, we analyzed how oscillations are damped in chemical networks and how critical frequencies (at the onset of strong damping) depend on reaction rates in the network.

Propagation of Oscillating Chemical Signals through Reaction Networks
Rafał Roszak, Michał D. Bajczyk, Ewa P. Gajewska, Robert Hołyst, Bartosz A. Grzybowski

Angewandte Chemie International Edition, Volume 58, Issue 14, March 26, 2019, Pages 4520-4525


Akin to electronic systems that can tune to and process signals of select frequencies, systems/networks of chemical reactions also “propagate” time‐varying concentration inputs in a frequency‐dependent manner. Whereas signals of low frequencies are transmitted, higher frequency inputs are dampened and converted into steady‐concentration outputs. Such behavior is observed in both idealized reaction chains as well as realistic signaling cascades, in the latter case explaining the experimentally observed responses of such cascades to input calcium oscillations. These and other results are supported by numerical simulations within the freely available Kinetix web application we developed to study chemical systems of arbitrary architectures, reaction kinetics, and boundary conditions.




Krzysztof Sozański, PhD, decided to pursue his career in business. Good luck and thank you!



We are looking for undergrad students within Sonata Bis project dealing with the stability of viruses. We offer 1200 PLN/month scholarship during 2019/2020 academic year.


From 23rd to 27th of January we hosted Dr David Martínez Martín from ETH Zurich. David gave an extraordinary lecture as a part of Dream Chemistry lecture series. He presented his work on measuring the mass of a single cell. It was a pleasure and we are looking to meet David in near future!


On 23rd of January 2019 Krzysztof Szczepański defended his PhD thesis entitled: "Study of diffusion of fluorescent nanoparticles inside human cell cytoplasm". Congrats!


The new paper from our group was published recently in Phys. Chem. Chem. Phys.!

Fluorescence correlation spectroscopy for multiple-site equilibrium binding: a case of doxorubicin–DNA interaction

by Xuzhu Zhang, Andrzej Poniewierski, Krzysztof Sozański, Ying Zhou, Anna Brzozowska-Elliott and Robert Holyst, DOI: 10.1039/C8CP06752J.
Read more here: https://pubs.rsc.org/…/c…/articlelanding/2019/cp/c8cp06752j…


The  Scientific Committee called upon to accept last year research works of our Institute decided to award poster by K. Makuch, R. Hołyst, T. Kalwarczyk, P. Garstecki, and J. F. Brady entitled Diffusion and flow in complex liquids, which was presented during Microsympsium 2018. Congratulations!


Two persons from our group were chosen this year for a new cadency of the PhD Students Council – MSc Patrycja Kuźma and MSc Eng. Karolina Paszkowska. MSc Patrycja Kuźma was elected as the President of the Council. Congratulations!


From 26th of November to 9th of December Łukasz visited the group of Professor Stone at Princeton. On 6th of December Lukasz gave a talk describing the phage project!



We offer a full-time PhD Student position within the project "Method for quantification of internalization of chemical and biological molecules into living cells" - interdisciplinary studies on cellular uptake of fluorescent probes. The goal of the project is the development of a novel quantitative and qualitative method for the determination of internalization of chemical and biological molecules into human cells. The PhD student will be involved in interdisciplinary activities including advanced microscopy and spectroscopy, cell culture (2D and 3D), molecular biology, biochemistry, application of microfluidic solutions, and data processing. We are looking for motivated candidates who are able to work at the edge of chemistry, biology, and physics. The project is led by Dr. Karina Kwapiszewska.

Details: http://ichf.edu.pl/2018-12-10%20(26)_drnt_Kwapiszewska.pdf


Three papers authored by members of our group were among seven papers chosen as best works published in IPC PAS in 2017.

Sozański et al. won second prize:

Quantitative fluorescence correlation spectroscopy in three-dimensional systems under stimulated emission depletion conditions, K. Sozański, E. Sisamakis, X. Zhang, R. Hołyst, Optica 4(8) 982-988, 2017, DOI 10.1364/OPTICA.4.000982

and two other papers were honorary mentioned:

Interference-like patterns of static magnetic fields imprinted into polymer/nanoparticle composites, Zhijie Yang, Jingjing Wei, Konrad Giżyński, Myung-Geun Song, Bartosz A. Grzybowski, Nature Communications, 8, 1564 (2017)

Dense layer of bacteriophages ordered in alternating electric field and immobilized by surface chemical modification as sensing element for bacteria detection, Richter, Ł.; Bielec, K.; Leśniewski, A.; Łoś, M.; Paczesny, J.;  Hołyst, R. ACS Appl. Mater. Interfaces, 2017, 9 (23), pp 19622–19629, DOI: 10.1021/acsami.7b03497


On 7th of November Karolina Księżarczyk and Karolina Paszkowska officially started their PhD studies at the Institute of Physical Chemistry PAS. The ceremony was held on 2 PM in the main hall.

Visit YouTube to see oath.

During the inauguration event Krzysztof Sozański, PhD, gave a plenary talk entitled Fluorescence at your service. New PhD students warmly appreciated this interesting talk.


Dr Anna Maciołek gave an invited talk during Venice meeting on Fluctuations in small complex systems IV at Instituto Veneto Di Scienze, Lettere Ed Arti Palazzo Franchetti, Venezia, 14th To 18th October 2018 entitled:

Current-mediated synchronization of a pair of beating non-identical flagella  



Sersitive was awarded a platinum medal during the International Warsaw Invention Show 2018 (15-17.10.2018) for the invention

A method of depositing metal nanoparticles on a surface in an electrochemical process, the surface obtained by this method and its application

authored by: Monika Księżopolska-Gocalska, Paweł Albrycht, Ewa Roźniecka, Joanna Niedziółka-Jӧnsson, Marta Podrażka, Robert Hołyst


MSc Eng. Agnieszka Wiśniewska, Msc Eng. Lukasz Richter, Xuzhu Zhang, PhD, Konrad Giżyński, PhD and Jan Paczesny, PhD were awarded within "Young Scientists of IPC PAS" competition in 2018. Laureates are chosen among PhD students and Postdocs under 35 years old based on the impact factor of journals in which they published within the last 3 years.




Jan Paczesny, PhD was elected to become representative of assistants and adjuncts in the Scientific Council of the Institute of Physical Chemistry PAS.



Yet another paper appeared from our group. Anna Maciołek together with Sutapa Roy (Max-Planck-Institut für Intelligente Systeme and Universität Stuttgart) coauthored a publication entitled: "Phase separation around a heated colloid in bulk and under confinement", which was accepted for publication in Soft Matter.




Robert Holyst was invited to give a talk at the students conference YoungChem 2018 http://www.youngchem.com/ entitled "Excellence in research".



Robert Holyst gave an invited talk "Storage and flux of energy in non-equilibrium stationary states"(http://th.if.uj.edu.pl/indico/event/6/contribution/41) at the 31st Smoluchowski Symposium on Statistical Physics. He presented a new methodology for the analysis of systems far from equilibrium and provided a variational principle for these states. He showed that for the fixed flux of energy flowing through the system, the non-equilibrium state minimizes the energy stored in the system in excess over its equilibrium value. The principle works for Rayleigh-Benard convective cell.



Jan Paczesny, PhD, attended one of the biggest conferences on materials science. European Materials Research Society 2018 Fall meeting was held in Warsaw from 17th to 20th of September. Janek presented a poster related to work on bacteriophages.



Konrad Giżyński, PhD, joined the group. He is post-doc within Sonata Bis grant.

Konrad previously worked with Professor Górecki at IPC PAS and with Professor Grzybowski at UNIST/IBS in South Korea.



Our labs are all full of students doing summer internships. We even arrange couches in the labs for them to be comfortable! Here, Kamila Kurzajak and Adam Kowalski are doing FCS measurements under supervision of Grzegorz Bubak, PhD.

If you study chemistry, physic, biology, or biotechnology and would like to work in our labs on real scientific problems don`t hesitate and send the application.



Our college DSc Anna Maciołek together with Professor Siegfried Dietrich from Max-Planck-Institut für Intelligente Systeme and Universität Stuttgart, published an article in Reviews of Modern Physics (Impact Factor = 36.367)! Congratulations!

Collective behavior of colloids due to critical Casimir interactions

A. Maciołek and S. Dietrich

Reviews of Modern Physics, just accepted manuscript (you can read arXiv version here and published version here)


Dr Karina Kwapiszewska was awarded "Lider" grant from The National Centre for Research and Development for her project on "Method for quantification of internalization of chemical and biological molecules into living cells". Congrats!

New PhD position will be opened within the project form April 2019.

You can read more here.


SERSitive: New substrates make it possible to routinely detect one molecule in a million.

The wide use of SERS has so far been radically limited due to the poor quality of the substrates on which the test solution had to be applied in order to obtain adequate signal enhancement. At the Institute of Physical Chemistry of the Polish Academy of Sciences (IPC PAS) in Warsaw, prototype substrates meeting all the requirements necessary to transform SERS into a routine, common laboratory technique were presented as far back as several years ago. Now, after further improvements and tests, new substrates, with ISO standards, are becoming available to all interested parties thanks to the SERSitive initiative (www.sersitive.eu) operating within the IPC PAS and Soft Condensed Matter group. The person in charge is Monika Księżopolska-Gocalska.

You can read more here.


New members joined our crew! We are very happy to welcome new PhD students:
MSc. Karolina Księżarczyk and MSc. Eng. Karolina Paszkowska. They will work within Sonata Bis grant (leader Jan Paczesny) on modulation of stabilitty of virions.


Airit organized kayaking for the whole group! We were kayaking on the Swider river.


New members joined our crew! We are very happy to welcome new undergraduate students: Aleksandra Borkenhagen, Jacek Kędzierski, who will do the research for their master theses, Kamila Kurzajak, Adrian Walkowiak and Adam Kowalski, who are doing summer internships in the group.


Our lab was visited for one month by Dr Debabrata Deb from India, who together with Robert Holyst worked on the modified Fermi-Ulam-Pasta model.


Łukasz Richter and Jan Paczesny together with Marta Janczuk-Richter (Surface Nanoengineering group) attended the Viruses of Microbes conference in Wroclaw, Poland (9th to 13th of July 2018). Łukasz gave a talk in front of 500 people audience! Janek and Marta presented posters.


Łukasz Richter co-authored a paper comming from Joanna Niedziolka-Jonsson group! The paper was recently accepted for publication in Sensors and Actuators B. ​

Capturing fluorescing viruses with silver nanowires ​

J. Grzelak, K. Sulowska, A. Leśniewski, E. Roźniecka, M. Janczuk-Richter, Ł. Richter, M,Łoś, M. Jönsson-Niedziółka, S. Maćkowski, J. Niedziółka-Jönsson ​

Sensors and Actuators B: Chemical, Volume 273, 10 November 2018, Pages 689-695

You can read it here.


Łukasz Richter attended the conference in Miami, USA. 28th Anniversary World Congress on Biosensors started on 12th of June and will finish on 15th of June. Łukasz presented results on phage-based biosensors.


A new paper on fission mechanism was published in collaboration with the Laboratory of Bioenergetics and Biomembranes, Department of Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences. It was published in Scientific Reports!

Insight into the fission mechanism by quantitative characterization of Drp1 protein distribution in the living cell

B. M. Michalska, K. Kwapiszewska, J. Szczepanowska, T. Kalwarczyk, P. Patalas-Krawczyk, K. Szczepański, R. Hołyst, J. Duszyński & J. Szymański

Scientific Reports volume 8, Article number: 8122 (2018) (see here)



Xuzhu Zhang defended his PhD thesis entitled "Determination of the intermolecular interactions in solutions from the motion of single molecules". His thesis was reviewed by prof. dr hab. Adam Patkowski (UAM) and prof. dr hab. Józef Moscicki (UJ). Congrats!


Łukasz Richter received a PRELUDIUM grant (70 000 PLN) from National Science Centre! The title of the project is: "Development of fast and efficient deposition of analyte in the electric field for the improvement of sensing and biosensing". Congratulations!



A new member joined our crew! We are very happy to welcome our new Post-doc – Nirmal Das. He defended his PhD in IISER Bhopal, India under the supervision of Professor Saptarshi Mukherjee in November 2017. His research interests include spectroscopic investigations of the organized assemblies, synthesis, and spectroscopic applications of luminescent metal nanoclusters.


Robert Holyst delivered a talk entitled " Metabolism at the nanoscale in cells." at the Fourth Biological Diffusion and Brownian Dynamics Brainstorm Meeting on April 16-18, 2018. Biological Diffusion and Brownian Dynamics Brainstorm 4 (BDBDB4) will, like the previous meetings (BDBDB 1-3), provide a forum for intensive discussions about the current state of experimental and theoretical studies of biological diffusion, with a focus on the Brownian Dynamics method for simulating biological macromolecules. The first BDBDB meeting was held in 2007 and they have taken place at irregular intervals since then.


DSc Anna Maciołek published a paper summarizing work within Harmonia grant, in which she was a leader.

Solvent coarsening around colloids driven by temperature gradients

Sutapa Roy, Siegfried Dietrich and Anna Maciolek

PHYSICAL REVIEW E 97, 042603 (2018) (you can read it here)


Thanks to the courtesy of Prof. Adam Patkowski and Prof. Jacek Gapiński we had a short visit to Adam Mickiewicz University in Poznań. Krzysztof Sozański and Łukasz Richter had opportunity to work with single particle tracking on Nanosight.

Additionally, Łukasz Richter gave a talk entitled: “Bacteriophages as a tool against bacteria”.



Jan Paczesny gave a plenary lecture during a meeting of the Scientific Association of Chemists of Adam Mickiewicz University in Jeziory on 24th of March 2018. The talk was on work done in IPC PAS within the last 5 years by Jan Paczesny and coworkers.


Jan Paczesny came back from his post doc experience and again works as an adjunct assistant professor in the Institute of Physical Chemistry PAS. ​ He obtained a grant from National Science Centre within SONATA BIS program and will start forming a new team for phage-related work. You are welcome to apply for MSc, PhD or post doc positions.


Łukasz Richter was on two-month internship in group of Prof. Francesco Stellacci in École Polytechnique Fédérale de Lausanne (EPFL, Lausanne, Switzerland). He worked on nanoparticles that are virusostatic or virucidal against bacteriophages.


We are very proud to present a brand new press release from our group! Xuzhu Zhang and Krzysztof Sozański describe their newest publication about the marriage of super-resolution microscopic technique and chemical reactions:



It is our pleasure to inform you about our recent publication entitled "Nanoscopic Approach to Quantification of Equilibrium and Rate Constants of Complex Formation at Single-Molecule Level" from Xuzhu Zhang, Evangelos Sisamakis, Krzysztof Sozański, Robert Hołyst in the Journal of Physical Chemistry Letters (IF=9.345!).

In this paper, we provide analytical autocorrelation formulas for probes undergoing diffusion-reaction processes under STED conditions. We support the theoretical analysis of experimental STED-FCS data on a model system of dye−micelle, where we retrieve the equilibrium and rates constants.

For more details, please find the publication here.


We are happy to announce that our first invited review about bacteriophages was accepted for publication in Drug Discovery Today (IF=6.369).

Recent advances in bacteriophage-based methods for bacteria detection

Richter, Ł.;† Janczuk-Richter, M.;† Niedziółka-Jönsson, J.; Paczesny, J.;* Hołyst, R.* ​

† equal contribution * corresponding authors

You can read it here.


Kinga Matula is back from Nijmegen, where she worked in Professor Huck group as visiting researcher for a month. She performed experiments on cancer cells traveling in blood.


Katarzyna Kryszczuk, the PhD student in our group, took part in a discussion about PhD studies in close future. The summing up of this discussion was published in Dziennik Gazeta Prawna. She highlighted there that Institute Physical Chemistry PAS has one of the highest efficiency of PhD studies in Poland and is supporting the mobility of PhD students.


New PhD student joined our group! Patrycja Kuźma graduated from Adam Mickiewicz University (AMU) in Poznań; Faculty of Chemistry. She gained her Msc Degree in Biological Chemistry in 2017. During Bachelor study she participated in an academic internship at Humboldt Universitat in Berlin in prof. Erhard Kemnitz Research Group. In July 2017, she received the award for the best student of the Department of Chemistry at Adam Mickiewicz University granted by Santander UNIVERSIDADES and Rector of AMU. Her main scientific interests are complex ion reactions in biochemical systems and nanotechnology. Welcome Patrycja and we wish you luck!


Robert Hołyst and Krzysztof Bielec visited Wrocław University of Technology. During that visit Krzysztof Bielec had presentation concerning method Time of Search (ToS) for Professor Aleksander Weron's group.


A paper by Jan Paczesny, Kinga Matuła, and Robert Hołyst on thin films of zinc oxide nanocrystallites has been awarded the prize for the best paper published in our Institute in 2016. Congratulations!



Throughout last week we hosted in our group prof. Carlos Drummond from Centre de Recherche Paul Pascal, University of Bordeaux. Prof. Drummond gave a talk entitled “From fire ants to graphene: some considerations on water-hydrophobic interfaces”.


Kinga Matuła and Łukasz Richter took part in the preparation of the scientific video where Marianna Kozłowska talked about ‘Shades of carbon’. This is a part of ADAMED SmartUP project that promotes science. We encourage you to see the video:



We are very proud to present our first publication about in vivo FCS in living cells! This work, based on in vivo and in vitro measurements, as well as in silico simulations, provides a consistent analysis of the diffusion of polydisperse nanoparticles in the cytoplasm of living cells. He encourages you to read it here:



Kinga Matuła gave a talk during Fall Meeting 2017 Conference organized by the European Material Research Society in Warsaw. She spoke about E.coli bacteria under mechanical stress in the 'Engineering surfaces to control and elucidate cellular response' session.



Kinga Matula and Lukasz Richter are among the winners of the prestigious "Mobility of Young Researchers of IPC PAS" competition. They will become visiting scholars for around a month in 2018 in the Professor Wilhelm Huck group in Holland and Professor Francesco Stellacci group in Switzerland, respectively.


STED-FCS allows to look at motion, concentration, and reactions of single molecules in an extremely small and well-localized spot. This makes it a great tool for biological and biophysical studies in cells. Although it works perfectly fine in 2D (so, for example, in membranes), it reveals surprising and severe issues in the 3D case -- which is why it has not been broadly applied to cell cytoplasm or any other bulk systems. Until now. In our new paper, we combine experiments with theory to explain the apparent inconsistencies of STED-FCS in 3D, provide experimental guidelines for such studies and determine the limitations of the method. The project was developed in collaboration with PicoQuant and its results have just been published in Optica; you can check it out here:



Łukasz Fura defended his master thesis (5!) on the influence of electromagnetic field on the viability of bacteria. He became MSc Eng. Congrats! He was wroking under supervision of Dr Monika Petelczyc (Warsaw University of Technology), Kinga Matuła and Prof. Robert Hołyst (IPC PAS).


Kinga Matuła, Krzysztof Sozański, Airit Agasty and Robert Hołyst attended 5th Conference on Nano- and Micromechanics organized in Wrocław (04-06.07.2017). Kinga Matuła gave a talk about mechanoevolution of bacteria under nanomechanical stress.

Krzysztof Sozański was invited speaker and he was talking about "How to Break a Molecular Motor: A Study of Kinesin Motion in Crowded Environment". Dr. Sozański got a price for the best talk competition results! Congrats Krzyś!


The new member just joined our team! Grzegorz Bubak will be Post-Doctoral Research Assistant in our group. He graduated in Industrial Biotechnology (2012), from the Faculty of Chemistry of the Warsaw University of Technology (Poland). He received his PhD in Robotics, Cognition, and Interaction Technologies at the Italian Institute of Technology, Genoa. From June 2016 he was a Post-Doctoral Research Assistant at the Centre of New Technologies, University of Warsaw. Welcome Grzesiek and good luck!


The best paper on the viscosity of polymer solutions ever published!! Our last publication in Macromolecules not only gives a proper equation for the viscosity of mixtures at the macroscale but also at the nanoscale. It allows to predict diffusion rates of nanoscaled probes in polymer solution mixtures and can be adapted to various multi length-scale complex systems.

You can read more here:



Karina Kwapiszewska and Krzysztof Szczepański visited Taipei (Taiwan) to attend the conference Single-Cell Biophysics: Measurement, Modulation, and Modeling. There they presented posters "In situ Quantitative Analysis of Protein Oligomerization in Living Cells" and "Cell Cycle-Dependent Fluctuations of Protein Mobility in Cytoplasm of HeLa Cell".


Our four PhD students: Agnieszka Wiśniewska, Kinga Matuła, Xuzhu Zhang, and Łukasz Richter are among the winners of the prestigious competition “Young researchers Institute of Physical Chemistry PAS”. Congrats to all of them!



On the 12th and 13th of June we have hosted Robert Evans, the distinguished Professor and the Royal Society Fellow from the University of Bristol in UK. He gave a talk entitled "Physicist's View of Hydrophobicity: Drying and the role of density fluctuations".


Yet another paper from our group has recently appeared. This time we described method to create densely packed layers of properly ordered phages for bacteria detection. You can find it here:


Richter, Ł.; Bielec, K.; Leśniewski, A.; Łoś, M.; Paczesny, J.; Hołyst, R. “Dense layer of bacteriophages ordered in alternating electric field and immobilized by surface chemical modification as sensing element for bacteria detection”, ACS Applied Materials & Interfaces 2017


Łukasz Richter gave an invited talk in Science Club of Biotechnologists “Herbion” at the Faculty of Chemistry Warsaw University of Technology. He was talking about his scientific interests and topics, whether it is worth starting PhD studies and what are pros and cons of such a career path.


Xuzhu Zhang attended the conference (Biomolecules and Nanostructures 6) in Podlesice near Kroczyce in the Krakow-Czestochowa Upland (Polish Jura). Key topics of the conference covered current subjects on the crossroads of molecular biology, physics and chemistry, including biomolecules, nanostructures, nanomachines, biosensors. In this conference Xuzhu presented a poster entitled "Tracking Structural Transitions of Bovine Serum Albumin in Surfactant Solutions by Fluorescence Correlation Spectroscopy and Fluorescence Lifetime Analysis".


Łukasz Richter attended 5th International Conference on Bio-Sensing Technology (BITE2017) organized in Riva del Garda (Italy). He presented a poster about phage-based bioconjugates for fast bacteria detection.


A new paper from our group was published. Taylor Dispersion Analysis (TDA) is a fast and easy to use method for the study of denaturation proteins as we have shown in our latest publication in PLOS ONE. You can read it here:


Jelińska A, Zagożdżon A, Górecki M, Wisniewska A, Frelek J, Holyst R (2017) Denaturation of proteins by surfactants studied by the Taylor dispersion analysis. PLoS ONE 12(4): e0175838


Karina Kwapiszewska and Krzysztof Szczepański visited Univerity of Edinburgh's School of Physics and Astronomy. During their stay, they collaborated with dr Vincent Martinez and dr Jochen Arlt. There they aimed to observe and measure movements of the content of human cell cytoplasm using a novel technique - differential diffusive microscopy. The visit was co-founded by European Soft Matter Infrastructure and ERA Chair - CREATE grant.


Kinga Matuła and Łukasz Richter are two from the group of seven brilliant scientists from the IPC PAS that are involved in the realization of workshops and lectures within grant “University of the young researcher”. They expanded kids' knowledge about bacteria and viruses during presentations. Students will test "natural antibiotics" during the session with Kinga and will make plaques of bacteriophages together with Łukasz.


Kinga Matuła completed a second edition of "Master and student - Nanoworld" program (11.03-08.04.17) for children as part of Children's University. Krzysztof Bielec was helping Kinga during each session and together with Łukasz Richter were experts who evaluated student's projects during last formal meeting with parents. Children designed new antibacterial materials based on gold nanoparticles with application in medicine and cosmetics.


We are very happy to welcome new PhD student in our group! Ying Zhou will start her PhD studies under the supervision of Professor Robert Holyst. She graduated from the Department of Clinical Laboratory Medicine, Chengdu University of Traditional Chinese Medicine (T.C.M) in 2013, then received her Master degree in Medicine from Dalian Medical University in 2016. Good luck!


New PhD student joined our team! Airit Agasty is from the city of Durgapur (about 160 kms from Kalkutta) in eastern India. He has a Bachelor's degree in Mechanical Engineering from Jadavpur University of Kalkutta, India which he completed in 2012, and he has a Master's degree in Rubber Technology from the Indian Institute of Technology, Kharagpur which he finished in 2016. His entire Master's final year research and thesis work were performed at the Leibniz Institute of Polymer Research in Dresden, Germany on a DAAD scholarship.


Robert Holyst delivered a lecture for students from the Jagiellonian University in Cracow. He talked about motion in liquids. His lecture started with the famous Richard Feynmann sentence: If, in some cataclysm, all of the scientific knowledge were to be destroyed, and only one sentence passed on to the next generation of creatures, what statement would contain the most information in the fewest words? I believe it is the atomic hypothesis that all things are made of atoms — little particles that move around in perpetual motion, attracting each other when they are a little distance apart, but repelling upon being squeezed into one another.


Sen Hou and Robert Holyst visited State Key Laboratory of Medicinal Chemical Biology​ of Nankai University. The latter is in the top 10 among circa 2400 colleges and Universities in China. This official visit resulted in formal agreement between the Chinese scientific unit and our Institute. Our informal collaboration started in 2009 with the arrival of dr Sen Hou to our group. We have already published more than 10 papers with researchers from Nankai University and obtained two grants from China.


Our recently published article was featured on the front cover of Bioconjugate Chemistry (February 15, 2017, Volume 28, Issue 2)!

You can read more:



Robert Holyst has just won a prestigious contest of the National Science Center and got a Maestro grant (2.4 MPLN) entitled "New method for determination of equilibrium constant for complex formation, concentrations and diffusion coefficients in solutions and living cells at nanomolar down to a picomolar concentration of reagents". Three PhD positions, 2 MSc positions, and 1 postdoc position are available in our group. Only 8 such grants were awarded in all basic and technical sciences in Poland in this contest.


Tomasz Kalwarczyk is taking his internship in the lab of Prof. Mireille Claessens at the University of Twente (Netherlands; 05.02.2017-04.03.2017). He is interested in interactions between Parkinson's related protein alpha-Synuclein and the capsid proteins of plant viruses.


Łukasz Richter just started his two-month internship in the group of Professor Carlos Drummond in Centre de Recherche Paul Pascal (Bordeaux, France). He will be working on the behavior of ions in high-frequency electric fields using a technique called surface forces apparatus (SFA).



Yet another press release on the research preformed in our group. Bacteriophage-based bioconjugates are the thing now!

in English:


in Polish:



Katarzyna Kryszczuk took part in Narodowy Kongres Nauki on 26-27th of January 2017. The subject of the conference was "Paths of academic career and the development of young scientists." Discussion during the conference particularly focused on PhD studies and increasing of their level.


One theoretical paper "Analytical form of the autocorrelation function for the fluorescence correlation spectroscopy" by Robert Hołyst , Andrzej Poniewierski and Xuzhu Zhang has just published in the journal of Soft Matter. In this paper we derived a novel formula for FCS autocorrelation function to study diffusion and binding-unbinding interaction of dye molecules with non-fluorescent particles.

Article available here.


During The Annual Microsymposium in the Institute of Physical Chemistry PAS Marta Janczuk-Richter and Łukasz Richter presented the poster about our recent publication. The poster was awarded by the committee as one of the four best posters during the symposium.

Bacteriophage-based bioconjugates as a flow cytometry probe for fast bacteria detection

Janczuk, M.;† Richter, Ł.;† Hoser, G.; Kawiak, J.; Łoś, M.; Niedziółka-Jönsson, J.; Paczesny, J.*; Hołyst, R.*


Kinga Matula gave a talk on influence of nanomechanical stress on viability of cells during The Annual Microsymposium in the Institute of Physical Chemistry PAS (Main Auditorium, 10th of January 2017, 2.20 PM). Only few Researchers were asked to give oral presentation (eleven talks in 2017). Majority of projects conducted in IPC PAS was presented in form of posters (92 posters).


A paper on motion of a model motor protein in the crowded environment has been awarded the prize for best paper published in our Institute in 2015. You can find this effect of collaboration of our group with a team of prof. Diez from TU Dresden at


Small crowders slow down kinesin-1 stepping by hindering motor domain diffusion Sozański, K.; Ruhnow, F.; Wiśniewska, A.; Tabaka, M.; Diez, S.; Hołyst, R. Phys. Rev. Lett. 115, 2015


New publication of Lili Sun was accepted for publication by Scientific Reports as result of collaboration with the scientists of Nankai University and TEDA Hospital in TianJin, China.


Title: "Antibacterial and anticancer PDMS surface for mammalian cell growth using the Chinese herb extract paeonol(4-methoxy-2- hydroxyacetophenone)" Authors: Jiajia Jiao,# Lili Sun,# Zaiyu Guo,# (equal contribution) Sen Hou, Robert Holyst, Yun Lu, Xizeng Feng.


Throughout the last week of November we hosted in our group four gifted high-school students. As a part of the Institute's collaboration with the Polish Children's Fund, we provided the promising youth with a glimpse of how actual work in scientific laboratories looks like. Who knows: maybe this could be a start of some brilliant scientific career?


During 10th International Warsaw Invention Show invention of Łukasz Richter, Jan Paczesny, Monika Księżopolska-Gocalska and Robert Hołyst was awarded with platinum medal.

Method for deposition of analyte from solution onto the substrate for surface enhanced spectroscopy in the electric field Richter, Ł.; Paczesny, J,; Księżopolska-Gocalska, M.; Hołyst, R. P.412548, 02.06.2015



Katarzyna Kryszczuk has been chosen to the Management Board of National Representation of PhD students (KRD) on 3rd of December 2016 on the XVII National Congress of PhD students and XIII Ordinary Congress of Delegates. KRD is a statutory representative body of all PhD students in Poland. Congrats Kasia!

Fot. Marek Żołądek


New paper of Łukasz Richter and Jan Paczesny was accepted for publication as a result of collaboration with Marta Janczuk-Richter, Professor Kawiak and Dr Hoser, Professor Łoś and Professor Niedziółka-Jönsson. Congratulations!

Bacteriophage-based bioconjugates as a flow cytometry probe for fast bacteria detection Janczuk, M.;† Richter, Ł.;† Hoser, G.; Kawiak, J.; Łoś, M.; Niedziółka-Jönsson, J.; Paczesny, J.*; Hołyst, R.* Bioconjugate Chemistry IF=4.5


Katarzyna Kryszczuk has been chosen for vice-chairwoman of PhD Council Polish Academy of Science (RSD PAN) on 25th of November 2016 on the Annual Meeting of the PhD students of Polish Academy of Science. RSD PAN represents all PhD students in Polish Academy of Science

Fot. Krzysztof Kupiec


Kinga Matuła started a program of courses "Master and student" (26.11.16-14.01.17) for children as part of Children's University project which popularizes science. During the series of meetings she is talking about: work in microbiological laboratory, bacteria, virsues, nanoparticles. Student in age around 11 perform several experiments and as a final result they design new materials based on nanoparticles that possess unique antibacterial activity.



Łukasz Richter and Kinga Matuła gave interviews for discussion portal Otokoclub . Łukasz raised a subject of viruses and bacteriophages, whereas Kinga discussed the issue of antibiotic resistance and antibacterial usage of nanoparticles.




Kinga Matuła worked in group of Professor Wilhelm Huck in Nijemgen (Holland) on Radbound University within one-month internship (17.10-18.11.16). She was working on method of detection of circulating tumor cells in droplet-based microfluidics.


New PhD students joined our team! We are happy to announce that Yirui Zhang and Krzysztof Bielec officially started PhD studies. Good luck!


A new member joined our soft matter group! Dr. Katarzyna Wybrańska is a physical chemist who is focused on nanotechnology. She creates new nanomaterials and analyzes their aplicability. We keep our finger crossed for commercialization of her antibacterial nanocoatings!


Kinga Matula together with Artur Ruszczak and Michal Horka (professor Garstecki group) were awarded title Tutor of The Year 2015/2016 by children participating in Children's University. Congrats!


New paper of Jan Paczesny was accepted for publication as a result of collaboration with Marcin Runowski, MSc, Tomasz Grzyb, PhD, and Professor Stefan Lis (UAM, Poznan, Poland).

Title: "Preparation of Biocompatible, Luminescent-Plasmonic Core/shell Nanomaterials Based on Lanthanide and Gold Nanoparticles Exhibiting SERS Effects" Authors: Runowski, Marcin; Goderski, Szymon; Paczesny, Jan; Księżopolska-Gocalska, Monika; Ekner-Grzyb, Anna; Grzyb, Tomasz; Rybka, Jakub; Giersig, Michael; Lis, Stefan ​ Congrats!


Kinga Matuła, Krzysztof Sozański and Łukasz Richter participated in the 4th International Soft Matter Conference (ISCM 2016) in Grenoble, France (11.09-17.09.2016).


We are pleased to inform that paper of Xuzhu Zhang, Andrzej Poniewierski, Aldona Jelińska, Anna Zagożdżon, Agnieszka Wisniewska, Sen Hou, and Robert Hołyst was published in Soft Matter in September. Congratulations!

The title is "Determination of equilibrium and rate constants for complex formation by fluorescence correlation spectroscopy supplemented by dynamic light scattering and Taylor dispersion analysis"

Congratulations to the authors!


Sen Hou, Lili Sun and Piotr Trochimczyk attended 22nd International Workshop on “Single Molecule Spectroscopy and Super-resolution Microscopy in the Life Sciences” in Berlin, Germany. Lili and Sen presented poster entitled "Enhanced DNA nanoparticle formation in macromolecular crowding environment studied by fluorescence correlation spectroscopy". Piotr made an oral lecture entitled "How can macromolecular crowding inhibit biological reactions? The enhanced formation of DNA nanoparticles"



Kinga Matula, Tomasz Kalwarczyk and Lukasz Richter are laureates of "Mobility of Young Researcher of IPC PAS" ("Mobilnosc Mlodych Badaczy IChF") contest. Kinga will work in Professor Wilhelm Huck group at Radboud Univeristy (Nijmegen, Holland). Tomek will pay a visit to group of Professor Mireille Claessens and also group of Professor Jeroen J.L.M. Cornelissen, both in University of Twente (Netherlands). Lukasz is going to visit Bordeaux, France, to work in Centre de Recherche Paul Pascal in Professor Carlos Drummond group (Structure and Dynamics of Soft Matter).



Łukasz Richter was a guest of Katarzyna Burda from Newsweek Poland. This video interview is about mysterious biomimicry and it was done as a part of Spokesman for Science (Rzecznicy Nauki). You can watch it here.


Interview with our PhD student, Krzysztof Bielec in popular science magazine „Wiedza i Życie”! As the semi-finalist of FameLab 2016, Krzysztof Bielec was invited to answer a few questions about bacteriophages and possibilities of using them to defeat bacterial infections. We encourage to read the full text, available in hard copy.



Sen Hou, Piotr Trochimczyk and Lili Sun went to Girona, Spain to attend one Computation Chemistry conference entitled "Theory and Simulation Across Scales in Molecular Science". They presented there two posters, that raises great interest and fruitful discussions.


Sen Hou and Lili Sun just came back from three-month visit in Prof Douglas Weibel’s group in USA. They were working on the interaction of RecA protein and cell membrane lipid. They also paid several scientific exchanging visits to famous universities in USA to meet our cooperators’ groups, among others Prof Tang Wang in Florida Middle University in Orlando, Prof Aleksei Aksimentiev in UIUC, Marcin Tabaka, PhD in MIT and Prof Chenfeng Ke in Dartmouth College.



Yirui Zhang joined our group! She started her PhD studies under supervision of Professor Anna Maciołek. Yirui graduated from Department of Physics, Hong Kong Baptist University in 2013, then received her M.Sc. in Physics from University Stuttgart in 2015. Welcome!


We are happy to announce that during summer holiday we will host a few new interns in our group: Małgorzata Jabłońska, Marta Pilz and Aleksandra Dawidziak from University of Warsaw as well as Aneta Karpińska, Karol Ulatowski and Łukasz Fura from Warsaw University of Technology. Welcome and good luck!



Professor Robert Hołyst participated in workshops on innovative approaches to the computational studies of droplets with multiple ions, called “Computational methods for modelling multiply-charged droplets”. During the event Professor Hołyst gave very interesting invited speech entitled “Charged materials in alternating electric field”.

More info available here.


Łukasz Richter was a guest of Professor Anton Ficai from Department of Science and Engineering of Oxide Materials and Nanomaterials at University Politehnica of Bucharest. He also gave a lecture as an invited speaker.


Krzysztof Bielec defended his Master Thesis and became a new PhD student in our group. He studied at the Jagiellonian University and he prepared his Master Thesis under supervision of Agnieszka Skórska-Stania, Jan Paczesny and Łukasz Richter. Good job Krzysiek and keep it up!


Another PhD in our group! Aldona Jelińska is now officially a Doctor of Philosophy. Congrats to Aldona!



Agnieszka Wiśniewska, Aldona Jelińska and Professor Robert Hołyst participated in 2nd European Workshop on Taylor Dispersion Analysis in Copenhagen (Denmark). Professor Hołyst gave a lecture as an invited speaker. The TDA 2016 Workshop was organized on behalf of University of Montpellier, University of Copenhagen and Analytiker-Ringen, Danmarks Farmaceutiske Selskab.


We are happy to inform you that Anna Zagożdżon from our group is now a PhD. We are all very proud! Congratulations Ania!



Kinga Matuła was invited to give a talk in series of lectures called "Mam Ochotę na Chemię" organized by the Scientific Association of Chemists at the University of Warsaw "Fulleren" on the 12th of May 2016.


We are seeking motivated students for summer internships. At least three topics are available:
  • Nanostructures in biological applications,
  • Synthesis and analysis of bio-inspired nanomaterials,
  • The electric field in biological applications.

More details available here.


Łukasz Richter participated in 44th International Exhibition of Inventions in Geneve (Swiss). He was awarded with gold medal with the special congratulations of the jury and special prize granted by Korea Invention Promotion Association. Congrats!

Method for deposition of analyte from solution onto the substrate for surface enhanced spectroscopy in the electric field
Richter, Ł.; Paczesny, J,; Księżopolska-Gocalska, M.; Hołyst, R.
P.412548, 02.06.2015



New paper of Lili Sun was accepted for publication by Plos One as result of collaboration with the scientists of UIUC, Clemson University and Washington University in USA.


Title: "The hinge region strengthens the nonspecific interaction between Lac-repressor and DNA: a computer simulation study" Authors: Lili Sun, Marcin Tabaka, Sen Hou, Lin Li, Krzysztof Burdzy, Aleksei Aksimentiev, Christopher Maffeo, Xuzhu Zhang, Robert Holyst.



DSc Anna Maciołek will receive financial support (around 410k PLN) within Harmonia grant founded by National Science Centre. The title of the project is:
Active Brownian motion of functional microparticles in complex fluids in the bulk and under spatial confinement

Also PhD candidates are being recruited for the project!



Łukasz Richter is among winners of Student-Inventor 2016 competition. Five inventions prepared by students were chosen to present in Geneva during Innovation Expo in April 2016.

Łukasz was awarded for his work described in patent application
Method for deposition of analyte from solution onto the substrate for surface enhanced spectroscopy in the electric field
Richter, Ł.; Paczesny, J,; Księżopolska-Gocalska, M.; Hołyst, R.
P.412548, 02.06.2015



Three inventions were submitted to Eureka! DPG competition from Institute of Physical Chemistry PAS. All three of them are connected with our group!

  1. Method of preparation of biosensor containing organized layers of bacteriophages as sensing element and biosensor itself
    Jan Paczesny, Marcin Łoś, Łukasz Richter, Marcin Fiałkowski, Robert Hołyst

  2. Method for surface modification with nanocomposites, nanocomposite material and the use thereof
    Katarzyna Wybrańska, Jan Paczesny, Robert Hołyst, Marcin Fiałkowski

  3. Method for deposition of metallic nanoparticles onto the surface in electrochemical process, surface itself and the use of thereof
    Monika Księżopolska-Gocalska, Weronika Michałowicz, Marta Siek, Joanna Niedziółka-Jonsson, Marcin Opałło, Robert Hołyst
We are looking forward for the results of the competition!


DSc Anna Maciołek is given a set of lectures on Stochastic Dynamics lecture as a course for PhD students starting on 7th of March and ending on 11th of March 2016



Łukasz Richter and Janek Paczesny live in Polish Radio 1 on 29th of February at 8 PM!



Krzysztof Bielec in FameLab 2016 semifinal! Please come to Copernicus Science Centre and support Krzysztof on Saturday, 27th of February 2016!




Article about work of Łukasz Richter in Newsweek Poland! The piece was done as a part of Spokesman for Science (Rzecznicy Nauki) programme by Copernicus Science Centre. The idea of the programme is to bring scientist to cooperate with journalist to speak about polish science in intelligible way. You can read it here.


The scientific committee at the IPC PAS announced that posters presented by Kinga Matuła, Krzysztof Sozański and Anna Maciołek during annual reporting symposium were awarded in competition for outstanding posters.

K. Matuła, Ł. Richter, M. Janczuk, K. Kryszczuk, W. Nogala, B. Peplińska, M. Grzeszkowiak, E. Wyroba, N. Derebecka, J. Wesoły, T. Wrzeciński, J. Łoś, M. Łoś, J. Paczesny, R. Hołyst
Mechanoevolution of Escherichia coli: from Gram-negative toward Gram-positive strain.

K. Sozański, F. Ruhnow, A. Wiśniewska, M. Tabaka, S. Diez, R. Hołyst
How to break a molecular motor: A study of kinesin motion in crowded environment.

A. Maciołek
Action at a distance.


Janek Paczesny appeared recently twice in public media. He was a guest of Karolina Głowacka in radio TOK FM on 7th of January. The audition was on new elements, which fulfilled the 7th row of periodic table. Janek appeared also in TVN ("Dzień Dobry TVN") on 15th of January in material dealing with first scientific stand-up in Poland.


Krzysztof Sozański, Janek Paczesny and Robert Hołyst were invited to give talks during IPC PAS annual reporting symposium. Only the best papers from year 2015 were presented.


And yet another press release describing our recent work published in Sensors and Actuators B: Chemical. The paper describes our recently published method on orientation of bacteriophages in the electric field. Congrats to Łukasz Richter, Kinga Matuła and Janek Paczesny who did most of the work.

More about this method you can find in the press release note and in the paper.


A brand new paper on the mechanism of kinesin motion has been recently published in Physical Review Letters. Congrats to Krzysztof Sozański (first author) et consortes.
More details here: publisher web site.

Small Crowders Slow Down Kinesin-1 Stepping by Hindering Motor Domain Diffusion

Krzysztof Sozański, Felix Ruhnow, Agnieszka Wiśniewska, Marcin Tabaka, Stefan Diez, and Robert Hołyst

Phys. Rev. Lett. 115, 218102 (2015) - Published 20 November 2015


Another press release from our group.
This time, it concerns the new view of the evaporation process presented in a recent Soft Matter paper by Robert Hołyst et al.

A paper on self-assembly of liquid crystal/ZnO nanocrystals was just published in Chemistry – A European Journal (IF 5.73).The project was developed in collaboration with the Lewinski group and the lead author is dr Jan Paczesny. You can find it at http://onlinelibrary.wiley.com/doi/10.1002/chem.201502714/full.

Another PhD graduated from our group today. Big congrats to Witold Adamkiewicz, and good luck on your post-doc in South Korea!

Good news from the Ministry of Science! This year, four people form our group were awarded prestigious, three-year scholarships for outstanding young scientists. These are: Tomasz Kalwarczyk, Karina Kwapiszewska, Jan Paczesny and Krzysztof Sozański.

From now on, Krzysztof Sozański is officially a PhD. 

A comprehensive review on the length-scale dependent viscosity model, whose lead author is dr Tomasz Kalwarczyk, was just published by Advances in Colloid and Interface Science (IF 7.78). You can find it at http://www.sciencedirect.com/science/article/pii/S0001868615000925 .

Three members of our group: Kinga Matuła, Łukasz Richter, and Krzysztof Sozański, were qualified for the TransFormation.doc program organized by the Ministry of Science. They will participate in two-week soft skill courses at the world’s top universities. Learn – and spread the knowledge!

Lili Sun, Sen Hou and Robert Hołyst were involved in a collaboration with teams from Tianjin (China), which now brought a publication in Scientific Reports (IF 5.58). The article can be found at http://www.nature.com/articles/srep10464 .

Jan Paczesny on the radio, talking about science, financing and our Institute. Twice! You can find the recordings here: http://audycje.tokfm.pl/odcinek/25840 and here: http://rdc.pl/publikacja/popoludnie-rdc-stypendia-dla-mlodych-naukowcow/ .

Another START scholarship from the Foundation for Polish Science goes to our group – this time, thanks to dr Jan Paczesny.

Robert Hołyst co-authored a text in the News and Views section of the recent issue of Nature Physics,  http://www.nature.com/nphys/journal/v11/n4/full/nphys3297.html

Out of 25 semi-finalists of the prestigious popularization competition, FameLab Poland, three are from our group! These are: Kinga Matuła, Jan Paczesny, and Łukasz Richter. Congratulations, and best of luck in the finals!

The results of the science popularization competition INTER 2014, organized by the Foundation for Polish Science, are here – 3rd prize goes to dr Jan Paczesny for his talk on the rapid evolution of bacteria under mechanical stress. Congratulations! (http://www.fnp.org.pl/konkurs-popularyzatorski-inter-2014-rozstrzygniety/).

Our team returned from the 8th International Warsaw Invention Show IWIS 2014 with a total of four medals (one golden, two silver and a Glory Medal)! Congratulations to Jan Paczesny, WitoldAdamkiewicz, Krzysztof Sozański, Robert Hołyst and their collaborators from other groups as well as InInstitute of High Pressure Physics PAS.

Agnieszka Kowalska, Agnieszka WIśniewka, Kinga Matuła, Katarzyna Kryszczuk, Kinga Bar, Krzysztof Szczepański and XuzhuZhang from our group participated in the 2nd Warsaw-Cambridge WoungScientistsMeting. Best wishes of effective collaboration!

Congratulations to Jan Paczesny, who was awarded the 3rd degree Wojchiech Świętosławski memorial prize by the Polish Chemical Society. Also, this month a paper co-authored by Jan was published in Macromolecules (IF>5). Well done and keep it up! (http://pubs.acs.org/doi/abs/10.1021/ma500941c)

We have another paper in Nanoscale (IF 7.39) – this time, concerning the transport properties of colloidal and protein solutions. The lead author is Tomasz Kalwarczyk and the text can be found here: http://pubs.rsc.org/en/content/articlehtml/2014/nr/c4nr00647j .

Results of the 2014 edition of START scholarships were just announced by the Foundation for Polish Science. This year’s laureate from our group is Jan Paczesny. Congratulations!

We got two awards for the inventions on nanostructure ordering on surfaces and their application to SERS: first, the Student-Inventor award by the Kielce University of Technology, and soon afterward a silver medal at the 42nd International Exhibition of Inventions in Geneva. Congratulations to Jan Paczesny, Witold Adamkiewicz, Krzysztof Sozański, Robert Hołyst and their collaborators from other groups as well as InInstitute of High Pressure Physics PAS.

A stunning press release on the work conducted in our group on Taylor dispersion analysis! 

Swiss patent office awarded a new patent on a method of covering surfaces with functional monolayers of nanoparticle structures. The inventor from our Institute, dr Jan Paczesny, Krzysztof Sozański, dr Andrzej Żywociński and Witold Adamkiewicz collaborated on this project with the Institute of High Pressure PAS.

An interesting paper from our group on application of FCS to analysis of DNA assays was just published in Biosensors and Bioelectronics (IF 6.41). The lead author is dr Sen Hou. You can find it at http://www.sciencedirect.com/science/article/pii/S095656631300482X.

A paper from our team by Krzysztof Sozański, Agnieszka Wiśniewska, Tomasz Kalwarczyk and Robert Hołyst appeared in Physical Review Letters (IF 7.7). The topic is activation energy for motion in complex liquids, you can find the text here. (http://journals.aps.org/prl/abstract/10.1103/PhysRevLett.111.228301)

Another high IF paper from our group!  Results of Marcin Tabaka, Tomasz Kalwarczyk and Robert Hołyst on influence of crowding on gene regulation kinetics appeared in Nucleic Acids Research (IF>8). http://nar.oxfordjournals.org/content/early/2013/10/10/nar.gkt907.abstract

Dr Sen Hou was awarded with a scholarship of the Ministry of Science for young researchers. Congratulations!

Dr Jan Paczesny was awarded a scientist of the year 2013 prize by the influential magazine “Polityka”. Well done!

fot. Tadeusz Późniak/Polityka

A paper on determination of DNA labelling efficiency by Sen Hou, Lili Sun, Stefan Wieczorek, Tomasz Kalwarczyk, Tomasz Kamiński and RoberHołyst just appeared in Biosensor and Bioelectronics (IF>5). 

Interesting results on nano-windmills rotating on the water surface were just published in Nanoscale (IF>6). Congratulations to the authors: Patrycja Niton, Andrzej Zywocinski, Marcin Fiałkowski and Robert Hołyst. (http://pubs.rsc.org/en/content/articlelanding/2013/NR/C3NR03496H#!divAbstract

The laureates of the National Science Centre grant were announced and again we have some reasons to celebrate! Robert Hołyst will lead the OPUS grant (>900.000 PLN), while Sen Hou and Jan Paczesnyare starting SONATA projects (nearly 500.000 PLN each). The application by Sen Hou was rated first in the relevant topic panel. Congratulations, and good luck with the projects!

The Ministry of Science announced the results of Iuventus Plus grant competition. Tomasz Kalwarczyk and Jan Paczesny both received financing for their projects!

An MSc student from our team, Krzysztof Sozański, won a European Young Chemists’ Network Award for the best talk during the 15th Spring Symposium of JungChemikerForum GDCh in Berlin. Keep it up!

Another fascinating press release from our group – this time, it’s on biologistics, i.e. motion in living cells.

A paper on fabrication of self-assembled nanostructures for SERS platforms was just published in Chemistry of Materials (IF>7) Congratulations to Jan Paczesny, Witold Adamkiewicz, Krzysztof Sozański, Monika Wadowska, Robert Hołyst and their collaborators from other groups as well as InInstitute of High Pressure Physics PAS. ( http://pubs.acs.org/doi/abs/10.1021/cm3008914)

A handbook on thermodynamics by Robert Hołyst and Andrzej Poniewierski was published internationally by Springer. It gives a full theoretical introduction to the field along with novel applications and modern approaches. Study and enjoy! (http://www.sciencedirect.com/science/article/pii/S095656631300482X)

We just published a press material on the research on polymers in bacterial cytoskeleton conducted in our group.

Tomasz Kalwarczyk received a START scholarship for young scientists, granted by the Ministry of Science. Congratulations!

Krzysztof Sozański got a Diamond Grant from the Ministry of Science. It is the first edition of this grant contest for undergraduate students. The awarded project concerns macro- and nanoscaled viscosity of complex liquids.

A project on length-scale-dependent viscosity in living matter was awarded financing (nearly 3.000.000 PLN) by the National Science Centre within the MAESTRO program. The project will be led by Robert Hołyst.