ZB 10 - Soft Condensed Matter (R. Holyst)

Reduction of dimensionality in a diffusion search process and kinetics of gene expression

Author(s): Holyst, R and Blazejczyk, M and Burdzy, K and Goralski, G and Bocquet, L
Title: Reduction of dimensionality in a diffusion search process and kinetics of gene expression
Abstract: In order to activate a gene in a DNA molecule a specific protein factor) has to bind to the promoter of the gene. We and partially answer the following question: how much time a transcription factor, which activates a given gene, need in order find this gene inside the nucleus of a cell? The estimate based on simplest model of diffusion gives a very long time of days. We various mechanisms by which the time can be reduced to seconds, particular, the reduction of dimensionality, in which diffusion takes from three-dimensional space to two-dimensional space. The needed to keep the diffusing particle in 2D (i.e, at the of size L-2 in a volume of size L-3) should scale as U similar
Pages: 71-82
Journal: PHYSICA A
Volume: 277
ID: ISI:000085815500007
Year: 2000