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ZB 10 - Soft Condensed Matter (R. Holyst)

We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!

Publication

Accurate genetic switch in Escherichia coli: Novel mechanism of regulation by co-repressor

Author(s): Tabaka, Marcin and Cybulski, Olgierd and Holyst, Robert
Title: Accurate genetic switch in Escherichia coli: Novel mechanism of regulation by co-repressor
Abstract: Understanding a biological module involves recognition of its structure the dynamics of its principal components. In this report we present analysis of the dynamics of the repression module within the of the trp operon in Escherichia coli. We combine biochemical for reaction rate constants for the trp repressor binding to trp and in vivo data of a number of tryptophan repressors (TrpRs) bind to the operator. The model of repression presented in this greatly differs from previous mathematical models. One, two or TrpRs can bind to the operator and repress the transcription. reaction rates for detachment of TrpRs from the operator depend on tryptophan (Trp) concentration, since Trp can also to the repressor-operator complex and stabilize it. From the modeling and analysis of reaction rates and equilibrium emerges a high-quality, accurate and effective module of trp This genetic switch responds accurately to fast consumption Trp from the interior of a cell. It switches with minimal dispersion the concentration of Trp drops below a thousand molecules per cell. (C) 2008 Elsevier Ltd. All rights reserved.
Pages: 1002-1014
Journal: JOURNAL OF MOLECULAR BIOLOGY
Volume: 377
ID: ISI:000255108900003
Year: 2008
DOI: 10.1016/j.jmb.2008.01.060