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ZB 10 - Soft Condensed Matter (R. Holyst)
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!

Publication

Implications of macromolecular crowding for protein-protein association kinetics in the cytoplasm of living cells

Author(s): Tabaka, Marcin and Sun, Lili and Kalwarczyk, Tomasz and Holyst, Robert
Title: Implications of macromolecular crowding for protein-protein association kinetics in the cytoplasm of living cells
Abstract: We present a method of prediction of in vivo association rate constants proteins from in vitro rate constants. This model accounts for changes in length-scale dependent viscosity of the cytoplasm of a cell and interaction potential between proteins. We explain the results obtained for protein-protein association rate in the cytoplasm of HeLa cells determined by Phillip et al. Proc. Natl. Acad. Sci. U. S. A., 2012, 109, 1461.
Pages: 4386-4389
Journal: SOFT MATTER
Volume: 9
ID: ISI:000316967300003
Year: 2013
DOI: 10.1039/c3sm00013c

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