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ZB 30 - Hiperpolaryzacja jądrowa układów molekularnych i nanomateriałów (T.Ratajczyk) |
Publication
Variable-temperature NMR spectroscopy for metabolite identification in biological materials ,
Author(s): Nawrocka, Ewa K. and Urbańczyk, Mateusz and Koziński, Kamil and Kazimierczuk, Krzysztof ,
Title: Variable-temperature NMR spectroscopy for metabolite identification in biological materials ,
Abstract: Nuclear magnetic resonance is a “workhorse technique” used in metabolomics, complementary to mass spectrometry. Unfortunately, only the most basic NMR methods are sensitive enough to allow fast medical screening. The most common of them, a simple 1H NMR, suffers from low dispersion of resonance frequencies, which often hampers the identification of metabolites. In this article we show that 1H NMR spectra contain previously overlooked parameters potentially helpful in metabolite identification, namely the rates of temperature-induced changes of chemical shifts. We prove that they are reproducible between various metabolite mixtures and can be determined quickly when Radon transform is used to process the data.
Pages: 35321-35325 ,
Journal: RSC Adv. ,
Publisher: The Royal Society of Chemistry ,
Volume: 11 ,
Year: 2021
URL: http://dx.doi.org/10.1039/D1RA05626C ,
DOI: 10.1039/D1RA05626C ,