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ZB 10 - Soft Condensed Matter (R. Holyst)
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!

Publication

Single-molecule brightness analysis for the determination of anticancer drug interactions with DNA ,

Author(s): Zhou, Ying and Bielec, Krzysztof and Pasitsuparoad, Pakorn and Hołyst, Robert ,
Title: Single-molecule brightness analysis for the determination of anticancer drug interactions with DNA ,
Abstract: Anthracyclines are one of the most studied anticancer drugs approved for medical treatment. The equilibrium constant (K) of the reaction between these drugs with DNA in both in vitro and in vivo experiments lacks consensus. The K values vary from 104 up to 108 M−1, which suggest a 1000-fold error in determining the effective concentration needed to form the drug–DNA complex. Until 2014, only one study by García [J. Phys. Chem. B, 2014, 118, 1288–1295] showed that the binding of anthracycline representative doxorubicin occurs in two reactions. We support this result by brightness analysis at a single molecular level for the four most common anthracyclines: doxorubicin, daunorubicin, epirubicin, and idarubicin.
Pages: - ,
Journal: Analyst ,
Publisher: The Royal Society of Chemistry ,
Year: 2020
URL: http://dx.doi.org/10.1039/D0AN01108H ,
DOI: 10.1039/D0AN01108H ,

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