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ZB 10 - Soft Condensed Matter (R. Holyst)
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!

Publication

TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats

Author(s): Gawrys-Kopczynska, Marta and Konop, Marek and Maksymiuk, Klaudia and Katarzyna and Derzsi, Ladislav and Sozanski, Krzysztof and Robert and Pilz, Marta and Samborowska, Emilia and Dobrowolski, Leszek and Jaworska, Kinga and Mogilnicka, Izabella and Ufnal, Marcin
Title: TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats
Abstract: Trimethylamine-oxide (TMAO) is present in seafood which is considered to beneficial for health. Deep-water animals accumulate TMAO to protect such as lactate dehydrogenase (LDH), against hydrostatic stress (HPS). We hypothesized that TMAO exerts beneficial on the circulatory system and protects cardiac LDH exposed to produced by the contracting heart. Male, Sprague-Dawley and (SHHF) rats were treated orally either water (control) or TMAO. In vitro, LDH with or without TMAO exposed to HPS and was evaluated using fluorescence correlation TMAO-treated rats showed higher diuresis and natriuresis, arterial pressure and plasma NT-proBNP. Survival in SHHF-control 66\% vs 100\% in SHHF-TMAO. In vitro, exposure of LDH to HPS with or TMAO did not affect protein structure. In conclusion, TMAO mortality in SHHF, which was associated with diuretic, and hypotensive effects. HPS and TMAO did not affect LDH protein structure.
Journal: ELIFE
Publisher: ELIFE SCIENCES PUBLICATIONS LTD
Addres: SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
Volume: 9
ID: ISI:000547376700001
Year: 2020
DOI: 10.7554/eLife.57028

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