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ZB 10 - Soft Condensed Matter (R. Holyst)
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!

Publication

Evaluation of Ligand-Selector Interaction from Effective Diffusion Coefficient

Author(s): Bielejewska, Anna and Bylina, Andrzej and Duszczyk, Kazimiera and Fialkowski, Marcin and Holyst, Robert
Title: Evaluation of Ligand-Selector Interaction from Effective Diffusion Coefficient
Abstract: We present an analytical technique for determination of ligand-selector binding constants. The method is based on the measurements effective molecular diffusion coefficient of the ligand during flow through a long (approximately 25 m), thin (0.254 mm 0.05 mm ID) capillary with and without the selector. The data are using the Taylor dispersion theory. Bovine Serum Albumin (BSA) cyclodextrin (CD) were taken as model selectors. We have tested our on the following selector-ligand complexes: BSA with warfarin, noscapine, salicylic acid, and riboflavin, and cyclodextrin 4-nitrophenol. The results are in good agreement with data from the and with our own results obtained within classical This method works equally well for uncharged and charged compounds.
Pages: 5463-5469
Journal: ANALYTICAL CHEMISTRY
Volume: 82
ID: ISI:000279253300012
Year: 2010
DOI: 10.1021/ac1008207

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