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ZB 10 - Soft Condensed Matter (R. Holyst)

We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!
We are different, but we all do great Science; and we have a lot of fun doing it!

Publication

Taylor Dispersion Analysis in Coiled Capillaries at High Flow Rates

Author(s): Lewandrowska, Anna and Majcher, Aldona and Ochab-Marcinek, Anna and Tabaka, Marcin and Holyst, Robert
Title: Taylor Dispersion Analysis in Coiled Capillaries at High Flow Rates
Abstract: Taylor Dispersion Analysis (TDA) has been performed for analytes moving high flow rates in long, coiled capillaries. A thin injection zone of analyte is stretched by the flow and final distribution of of the analyte at the end of the capillary has the shape. The high flow rates in coiled capillary generate They convectively mix the analyte across the capillary. This reduces the width of the Gaussian distribution several times in to the width obtained in a straight capillary in standard We have determined an empirical, scaling equation for the width as function of the flow rate, molecular diffusion coefficient of the viscosity of the carrier phase, internal radius of the capillary, and external radius of the coiled capillary. This can be used for different sizes of capillaries in a wide range parameters without an additional calibration procedure. Our results of flow in the coiled capillary could not be by current models based on approximate solutions of the Navier equation. We applied the technique to determine the diffusion of the following analytes: salts, drugs, single amino acids, peptides (from dipeptides to hexapeptides), and proteins.
Pages: 4051-4056
Journal: ANALYTICAL CHEMISTRY
Volume: 85
ID: ISI:000317794800038
Year: 2013
DOI: 10.1021/ac4007792